Chapter 3, Evolutionary Change in Nucleotide Sequences 1. estimating the rate of evolution 2. reconstructing the evolutionary history of organisms NUCLEOTIDE SUBSTITUTION IN A DNA SEQUENCE Jukes and Cantor's one-parameter model (1969) subsitutions occur with equal probability among the 4 nucleotide types one-parameter model (α) Kimura's two-parameter model (1980) two-paramet..